system_id stringclasses 58
values | code stringlengths 1 84 | label stringlengths 0 1.79k | description stringlengths 3 4.22k ⌀ | parent_code stringlengths 1 30 ⌀ | status stringclasses 8
values | aliases listlengths 0 51 | extra stringlengths 2 2.32k ⌀ |
|---|---|---|---|---|---|---|---|
bio/ec | 1.1.1.97 | 3-hydroxybenzyl-alcohol dehydrogenase | null | 1.1.1.- | null | [
"m-hydroxybenzyl alcohol dehydrogenase"
] | {"catalytic_activity": ["3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.98 | (R)-2-hydroxy-fatty-acid dehydrogenase | null | 1.1.1.- | null | [
"D-2-hydroxy fatty acid dehydrogenase"
] | {"catalytic_activity": ["(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.99 | (S)-2-hydroxy-fatty-acid dehydrogenase | null | 1.1.1.- | null | [
"L-2-hydroxy fatty acid dehydrogenase"
] | {"catalytic_activity": ["(S)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.100 | 3-oxoacyl-[acyl-carrier-protein] reductase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)."], "comments": ["-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives", "over CoA derivatives as substrates."], "uniprot_count": 100} |
bio/ec | 1.1.1.101 | acylglycerone-phosphate reductase | null | 1.1.1.- | null | [
"palmitoyldihydroxyacetone-phosphate reductase"
] | {"catalytic_activity": ["1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone", "3-phosphate + NADPH + H(+)."], "comments": ["-!- Also acts on alkylglycerone 3-phosphate and alkylglycerol", "3-phosphate."], "uniprot_count": 14} |
bio/ec | 1.1.1.102 | 3-dehydrosphinganine reductase | null | 1.1.1.- | null | [
"3-ketosphinganine reductase",
"3-oxosphinganine:NADPH oxidoreductase",
"3-oxosphinganine reductase",
"D-3-dehydrosphinganine reductase",
"D-3-oxosphinganine:B-NADPH oxidoreductase",
"D-3-oxosphinganine reductase",
"DSR",
"KTS reductase"
] | {"catalytic_activity": ["sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)."], "uniprot_count": 28} |
bio/ec | 1.1.1.103 | L-threonine 3-dehydrogenase | null | 1.1.1.- | null | [
"TDH"
] | {"catalytic_activity": ["L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + NADH + H(+)."], "comments": ["-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to", "glycine.", "-!- This threonine-degradation pathway is common to prokaryotic and", "eukaryotic cells and the two enzymes involved form a c... |
bio/ec | 1.1.1.104 | 4-oxoproline reductase | null | 1.1.1.- | null | [
"cis-hydroxy-L-proline oxidase"
] | {"catalytic_activity": ["cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + NADH + H(+)."], "comments": ["-!- The enzyme, isolated from animals, is specific for 4-oxo-L-proline", "and cis-4-hydroxy-L-proline.", "-!- It has no activity with trans-4-hydroxy-L-proline."], "uniprot_count": 10} |
bio/ec | 1.1.1.105 | all-trans-retinol dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-", "retinal--[retinol-binding protein] + NADH + H(+)."], "comments": ["-!- The enzyme recognizes all-trans-retinol and all-trans-retinal as", "substrates and exhibits a strong preference for NAD(+)/NADH as", "cofactors.", "-!- Re... |
bio/ec | 1.1.1.106 | pantoate 4-dehydrogenase | null | 1.1.1.- | null | [
"Panthothenase"
] | {"catalytic_activity": ["(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.107 | pyridoxal 4-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["pyridoxal + NAD(+) = 4-pyridoxolactone + NADH + H(+)."], "comments": ["-!- The enzyme acts on the hemiacetal form of the substrate."], "uniprot_count": 3} |
bio/ec | 1.1.1.108 | carnitine 3-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["carnitine + NAD(+) = 3-dehydrocarnitine + NADH + H(+)."], "uniprot_count": 23} |
bio/ec | 1.1.1.109 | Transferred entry: 1.3.1.28 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.110 | aromatic 2-oxoacid reductase | null | 1.1.1.- | null | [
"(R)-4-hydroxyphenyllactate dehydrogenase",
"(R)-aromatic lactate dehydrogenase",
"indole-3-lactate dehydrogenase",
"indolelactate dehydrogenase"
] | {"catalytic_activity": ["(1) (R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + NADH + H(+).", "(2) (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) =", "3-(4-hydroxyphenyl)pyruvate + NADH + H(+).", "(3) 3-(indol-3-yl)lactate + NAD(+) = indole-3-pyruvate + NADH + H(+)."], "comments": ["-!- The enzymes from anaerobi... |
bio/ec | 1.1.1.111 | 3-(imidazol-5-yl)lactate dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) (S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate +", "NADH + H(+).", "(2) (S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate +", "NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.112 | indanol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) (S)-indan-1-ol + NAD(+) = indan-1-one + NADH + H(+).", "(2) (S)-indan-1-ol + NADP(+) = indan-1-one + NADPH + H(+)."], "comments": ["-!- 3(20)alpha-hydroxysteroids are also oxidized, more slowly."], "uniprot_count": 7} |
bio/ec | 1.1.1.113 | L-xylose 1-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["L-xylose + NADP(+) = L-xylono-1,4-lactone + NADPH + H(+)."], "comments": ["-!- Also oxidizes D-arabinose and D-lyxose."], "uniprot_count": 0} |
bio/ec | 1.1.1.114 | apiose 1-reductase | null | 1.1.1.- | null | [
"D-apiitol reductase",
"D-apiose reductase"
] | {"catalytic_activity": ["D-apiitol + NAD(+) = aldehydo-D-apiose + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.115 | ribose 1-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"NADP-pentose-dehydrogenase"
] | {"catalytic_activity": ["D-ribose + NADP(+) + H2O = D-ribonate + NADPH + 2 H(+)."], "comments": ["-!- Also acts, more slowly, on D-xylose and other pentoses."], "uniprot_count": 0} |
bio/ec | 1.1.1.116 | D-arabinose 1-dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.117 | D-arabinose 1-dehydrogenase [NAD(P)(+)] | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) D-arabinose + NADP(+) = D-arabinono-1,4-lactone + NADPH + H(+).", "(2) D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH + H(+)."], "comments": ["-!- Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose."], "uniprot_count": 2} |
bio/ec | 1.1.1.118 | glucose 1-dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["D-glucose + NAD(+) = D-glucono-1,5-lactone + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.119 | glucose 1-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["D-glucose + NADP(+) = D-glucono-1,5-lactone + NADPH + H(+)."], "comments": ["-!- Also oxidizes D-mannose, 2-deoxy-D-glucose and 2-amino-2-deoxy-D-", "mannose."], "uniprot_count": 2} |
bio/ec | 1.1.1.120 | galactose 1-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH + H(+)."], "comments": ["-!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose."], "uniprot_count": 4} |
bio/ec | 1.1.1.121 | aldose 1-dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["an aldopyranose + NAD(+) = aldono-1,5-lactone + NADH + H(+)."], "comments": ["-!- Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose,", "6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose."], "uniprot_count": 0} |
bio/ec | 1.1.1.122 | D-threo-aldose 1-dehydrogenase | null | 1.1.1.- | null | [
"(2S,3R)-aldose dehydrogenase",
"L-fucose dehydrogenase"
] | {"catalytic_activity": ["a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + NADH + H(+)."], "comments": ["-!- Acts on L-fucose, D-arabinose and L-xylose.", "-!- The animal enzyme was also shown to act on L-arabinose, and the", "enzyme from Pseudomonas caryophylli on L-glucose."], "uniprot_count": 8} |
bio/ec | 1.1.1.123 | sorbose 5-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"5-ketofructose reductase"
] | {"catalytic_activity": ["keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.124 | fructose 5-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"5-ketofructose reductase (NADP(+))",
"5-ketofructose reductase (NADP+)"
] | {"catalytic_activity": ["D-fructose + NADP(+) = 5-dehydro-D-fructose + NADPH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.125 | 2-deoxy-D-gluconate 3-dehydrogenase | null | 1.1.1.- | null | [
"2-deoxygluconate dehydrogenase"
] | {"catalytic_activity": ["2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH +", "H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.126 | 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase | null | 1.1.1.- | null | [
"2-keto-3-deoxy-D-gluconate dehydrogenase"
] | {"catalytic_activity": ["2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-", "dioxohexanoate + NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.127 | 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase | null | 1.1.1.- | null | [
"2-keto-3-deoxy-D-gluconate dehydrogenase",
"2-keto-3-deoxygluconate dehydrogenase"
] | {"catalytic_activity": ["2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-", "hexodiulosonate + NADH + H(+)."], "comments": ["-!- The enzyme from Pseudomonas acts equally well on NAD(+) or NADP(+),", "while those from Erwinia chrysanthemi and Escherichia coli are more", "specific for NAD(+)."], "uniprot_c... |
bio/ec | 1.1.1.128 | Deleted entry | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.129 | L-threonate 3-dehydrogenase | null | 1.1.1.- | null | [
"L-threonic acid dehydrogenase"
] | {"catalytic_activity": ["L-threonate + NAD(+) = 3-dehydro-D-erythronate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.130 | 3-dehydro-L-gulonate 2-dehydrogenase | null | 1.1.1.- | null | [
"2,3-diketo-L-gulonate reductase",
"3-keto-L-gulonate dehydrogenase"
] | {"catalytic_activity": ["(1) 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + NADH + H(+).", "(2) 3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + NADPH + H(+)."], "uniprot_count": 55} |
bio/ec | 1.1.1.131 | mannuronate reductase | null | 1.1.1.- | null | [
"mannonate dehydrogenase"
] | {"catalytic_activity": ["(1) D-mannonate + NAD(+) = D-mannuronate + NADH + H(+).", "(2) D-mannonate + NADP(+) = D-mannuronate + NADPH + H(+)."], "comments": ["-!- Formerly EC 1.1.1.180 and EC 1.2.1.34."], "uniprot_count": 0} |
bio/ec | 1.1.1.132 | GDP-mannose 6-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["GDP-alpha-D-mannose + 2 NAD(+) + H2O = GDP-alpha-D-mannuronate + 2 NADH +", "3 H(+)."], "comments": ["-!- Also uses the corresponding deoxynucleoside diphosphate derivative as", "a substrate."], "uniprot_count": 8} |
bio/ec | 1.1.1.133 | dTDP-4-dehydrorhamnose reductase | null | 1.1.1.- | null | [
"dTDP-4-keto-L-rhamnose reductase",
"dTDP-6-deoxy-L-mannose dehydrogenase"
] | {"catalytic_activity": ["dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH +", "H(+)."], "comments": ["-!- In the reverse direction, reduction on the 4-position of the hexose", "moiety takes place only while the substrate is bound to another", "enzyme that catalyzes epimerization at C-3 and C-5; t... |
bio/ec | 1.1.1.134 | dTDP-6-deoxy-L-talose 4-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose +", "NADPH + H(+)."], "comments": ["-!- Oxidation on the 4-position of the hexose moiety takes place only", "while the substrate is bound to another enzyme that catalyzes", "epimerization at C-3 and C-5."], "uniprot_count": 0... |
bio/ec | 1.1.1.135 | GDP-6-deoxy-D-talose 4-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose", "+ NADPH + H(+).", "(2) GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose", "+ NADH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.136 | UDP-N-acetylglucosamine 6-dehydrogenase | null | 1.1.1.- | null | [
"UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase"
] | {"catalytic_activity": ["UDP-N-acetyl-alpha-D-glucosamine + 2 NAD(+) + H2O = UDP-2-acetamido-2-", "deoxy-alpha-D-glucuronate + 2 NADH + 3 H(+)."], "comments": ["-!- This enzyme participates in the biosynthetic pathway for UDP-alpha-D-", "ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic", "acid), an impor... |
bio/ec | 1.1.1.137 | ribitol-5-phosphate 2-dehydrogenase | null | 1.1.1.- | null | [
"ribitol 5-phosphate dehydrogenase"
] | {"catalytic_activity": ["(1) D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + NADPH +", "H(+).", "(2) D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + NADH +", "H(+)."], "comments": ["-!- The enzyme, characterized from the bacterium Lactobacillus plantarum,", "can use both NAD(+) and NADP(+) as elect... |
bio/ec | 1.1.1.138 | mannitol 2-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"NADP-dependent mannitol dehydrogenase"
] | {"catalytic_activity": ["D-mannitol + NADP(+) = D-fructose + NADPH + H(+)."], "uniprot_count": 10} |
bio/ec | 1.1.1.139 | Transferred entry: 1.1.1.21 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.140 | sorbitol-6-phosphate 2-dehydrogenase | null | 1.1.1.- | null | [
"glucitol-6-phosphate dehydrogenase",
"ketosephosphate reductase"
] | {"catalytic_activity": ["D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH +", "H(+)."], "uniprot_count": 3} |
bio/ec | 1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [
"15-hydroxyprostaglandin dehydrogenase"
] | {"catalytic_activity": ["prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)."], "comments": ["-!- Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin", "D2 (cf. EC 1.1.1.196 and EC 1.1.1.197)."], "uniprot_count": 8} |
bio/ec | 1.1.1.142 | D-pinitol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-", "pentahydroxycyclohexanone + NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.143 | sequoyitol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-", "pentahydroxycyclohexanone + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.144 | perillyl-alcohol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["perillyl alcohol + NAD(+) = perillyl aldehyde + NADH + H(+)."], "comments": ["-!- Oxidizes a number of primary alcohols with the alcohol group allylic", "to an endocyclic double bond and a 6-membered ring, either aromatic", "or hydroaromatic."], "uniprot_count": 4} |
bio/ec | 1.1.1.145 | 3beta-hydroxy-Delta(5)-steroid dehydrogenase | null | 1.1.1.- | null | [
"3beta-hydroxy-5-ene steroid dehydrogenase",
"progesterone reductase"
] | {"catalytic_activity": ["a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid +", "NADH + H(+)."], "comments": ["-!- Acts on 3beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17-", "dione and on 3beta-hydroxypregn-5-en-20-one to form progesterone."], "uniprot_count": 34} |
bio/ec | 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase | null | 1.1.1.- | null | [
"corticosteroid 11beta-dehydrogenase"
] | {"catalytic_activity": ["an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH + H(+)."], "uniprot_count": 20} |
bio/ec | 1.1.1.147 | 16alpha-hydroxysteroid dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + NADPH + H(+).", "(2) a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.148 | estradiol 17alpha-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) 17alpha-estradiol + NAD(+) = estrone + NADH + H(+).", "(2) 17alpha-estradiol + NADP(+) = estrone + NADPH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-", "hydroxyprogesterone + NADH + H(+).", "(2) (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-", "hydroxyprogesterone + NADPH + H(+)."], "comments": ["-!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62)."], "... |
bio/ec | 1.1.1.150 | 21-hydroxysteroid dehydrogenase (NAD(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["pregnan-21-ol + NAD(+) = pregnan-21-al + NADH + H(+)."], "comments": ["-!- Acts on a number of 21-hydroxycorticosteroids."], "uniprot_count": 0} |
bio/ec | 1.1.1.151 | 21-hydroxysteroid dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate)",
"dehydrogenase",
"21-hydroxy steroid dehydrogenase",
"21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide",
"phosphate)",
"NADP-21-hydroxysteroid dehydrogenase"
] | {"catalytic_activity": ["pregnan-21-ol + NADP(+) = pregnan-21-al + NADPH + H(+)."], "comments": ["-!- Acts on a number of 21-hydroxycorticosteroids."], "uniprot_count": 0} |
bio/ec | 1.1.1.152 | 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase | null | 1.1.1.- | null | [
"etiocholanolone 3alpha-dehydrogenase"
] | {"catalytic_activity": ["3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-", "dione + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) L-erythro-7,8-dihydrobiopterin + NADP(+) = L-sepiapterin + NADPH +", "H(+).", "(2) (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-", "5,6,7,8-tetrahydropterin + 2 NADPH + 2 H(+)."], "comments": ["-!- This enzyme catalyzes the final step in the de novo synthesis of", "te... |
bio/ec | 1.1.1.154 | ureidoglycolate dehydrogenase [NAD(P)(+)] | null | 1.1.1.- | null | [
"ureidoglycolate dehydrogenase"
] | {"catalytic_activity": ["(1) (S)-ureidoglycolate + NAD(+) = N-carbamoyl-2-oxoglycine + NADH +", "H(+).", "(2) (S)-ureidoglycolate + NADP(+) = N-carbamoyl-2-oxoglycine + NADPH +", "H(+)."], "comments": ["-!- Involved in catabolism of purines.", "-!- The enzyme from the bacterium Arthrobacter allantoicus can use both", "... |
bio/ec | 1.1.1.155 | Transferred entry: 1.1.1.87 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.156 | glycerol 2-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"dihydroxyacetone reductase"
] | {"catalytic_activity": ["glycerol + NADP(+) = dihydroxyacetone + NADPH + H(+)."], "uniprot_count": 3} |
bio/ec | 1.1.1.157 | 3-hydroxybutyryl-CoA dehydrogenase | null | 1.1.1.- | null | [
"beta-hydroxybutyryl-CoA dehydrogenase",
"BHBD"
] | {"catalytic_activity": ["(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + NADPH + H(+)."], "uniprot_count": 12} |
bio/ec | 1.1.1.158 | Transferred entry: 1.3.1.98 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.159 | 7alpha-hydroxysteroid dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH", "+ H(+)."], "comments": ["-!- Catalyzes the oxidation of the 7alpha-hydroxy group of bile acids and", "alcohols both in their free and conjugated forms.", "-!- The Bacteroides fragilis and Clostridium enzymes can also ut... |
bio/ec | 1.1.1.160 | dihydrobunolol dehydrogenase | null | 1.1.1.- | null | [
"bunolol reductase"
] | {"catalytic_activity": ["dihydrobunolol + NADP(+) = bunolol + NADPH + H(+)."], "comments": ["-!- Also acts, more slowly, with NAD(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.161 | Deleted entry | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.162 | erythrulose reductase | null | 1.1.1.- | null | [
"D-erythrulose reductase"
] | {"catalytic_activity": ["D-threitol + NADP(+) = D-erythrulose + NADPH + H(+)."], "comments": ["-!- NAD(+) is also utilized, but more slowly."], "uniprot_count": 2} |
bio/ec | 1.1.1.163 | cyclopentanol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["cyclopentanol + NAD(+) = cyclopentanone + NADH + H(+)."], "comments": ["-!- 4-Methylcyclohexanol and cyclohexanol can also act as substrates."], "uniprot_count": 3} |
bio/ec | 1.1.1.164 | hexadecanol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["hexadecan-1-ol + NAD(+) = hexadecanal + NADH + H(+)."], "comments": ["-!- The liver enzyme acts on long-chain alcohols from C8 to C16.", "-!- The Euglena enzyme also oxidizes the corresponding aldehydes to fatty", "acids."], "uniprot_count": 0} |
bio/ec | 1.1.1.165 | 2-alkyn-1-ol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + NADH + H(+)."], "comments": ["-!- Acts on a variety of 2-alkyn-1-ols, and also on 1,4-butanediol.", "-!- NADP(+) also acts as acceptor, but more slowly."], "uniprot_count": 0} |
bio/ec | 1.1.1.166 | hydroxycyclohexanecarboxylate dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-", "hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H(+)."], "comments": ["-!- Acts on hydroxycyclohexanecarboxylates that have an equatorial", "carboxy group at C-1, an axial hydroxy group at C-3 and an equatorial", "hydrox... |
bio/ec | 1.1.1.167 | hydroxymalonate dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["hydroxymalonate + NAD(+) = oxomalonate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.168 | 2-dehydropantolactone reductase (Re-specific) | null | 1.1.1.- | null | [
"2-dehydropantolactone reductase (A-specific)",
"2-dehydropantoyl-lactone reductase (A-specific)",
"2-ketopantoyl lactone reductase",
"ketopantoyl lactone reductase"
] | {"catalytic_activity": ["(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)."], "comments": ["-!- The enzyme from Saccharomyces cerevisiae differs from that from", "Escherichia coli (EC 1.1.1.214), which is specific for the Si-face of", "NADP, and in receptor requirements from EC 1.1.99.26."], "uniprot_c... |
bio/ec | 1.1.1.169 | 2-dehydropantoate 2-reductase | null | 1.1.1.- | null | [
"ketopantoate reductase",
"ketopantoic acid reductase",
"KPA reductase"
] | {"catalytic_activity": ["(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)."], "uniprot_count": 43} |
bio/ec | 1.1.1.170 | 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) | null | 1.1.1.- | null | [
"3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase",
"(decarboxylating)",
"3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase",
"(decarboxylating)",
"3beta-hydroxy-4beta-methylcholestenoate dehydrogenase",
"sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)",
"sterol... | {"catalytic_activity": ["(1) a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid", "+ CO2 + NADPH.", "(2) a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid +", "CO2 + NADH."], "comments": ["-!- The enzyme participates in the biosynthesis of several important", "sterols such as ergoste... |
bio/ec | 1.1.1.171 | Transferred entry: 1.5.1.20 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.172 | 2-oxoadipate reductase | null | 1.1.1.- | null | [
"2-ketoadipate reductase",
"alpha-ketoadipate reductase"
] | {"catalytic_activity": ["2-hydroxyadipate + NAD(+) = 2-oxoadipate + NADH + H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.173 | L-rhamnose 1-dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + NADH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.174 | cyclohexane-1,2-diol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["trans-cyclohexane-1,2-diol + NAD(+) = 2-hydroxycyclohexan-1-one + NADH +", "H(+)."], "comments": ["-!- Also oxidizes, more slowly, the cis isomer and", "2-hydroxycyclohexanone."], "uniprot_count": 0} |
bio/ec | 1.1.1.175 | D-xylose 1-dehydrogenase | null | 1.1.1.- | null | [
"D-xylose dehydrogenase",
"NAD-D-xylose dehydrogenase",
"NAD-linked D-xylose dehydrogenase"
] | {"catalytic_activity": ["D-xylose + NAD(+) = D-xylono-1,5-lactone + NADH + H(+)."], "uniprot_count": 3} |
bio/ec | 1.1.1.176 | 12alpha-hydroxysteroid dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate +", "NADPH + H(+)."], "comments": ["-!- Catalyzes the oxidation of the 12alpha-hydroxy group of bile acids,", "both in their free and conjugated form.", "-!- Also acts on bile alcohols."], "uniprot_count": 2} |
bio/ec | 1.1.1.177 | glycerol-3-phosphate 1-dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"glycerin-3-phosphate dehydrogenase"
] | {"catalytic_activity": ["sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + NADPH", "+ H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.178 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | null | 1.1.1.- | null | [
"2-methyl-3-hydroxybutyryl-CoA dehydrogenase"
] | {"catalytic_activity": ["(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-", "CoA + NADH + H(+)."], "comments": ["-!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA."], "uniprot_count": 6} |
bio/ec | 1.1.1.179 | D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming) | null | 1.1.1.- | null | [
"D-xylose-NADP dehydrogenase"
] | {"catalytic_activity": ["D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)."], "comments": ["-!- The enzyme, characterized from pig arterial vessels and eye lens,", "also acts, more slowly, on L-arabinose and D-ribose. cf.", "EC 1.1.1.424."], "uniprot_count": 22} |
bio/ec | 1.1.1.180 | Transferred entry: 1.1.1.131 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.181 | cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase | null | 1.1.1.- | null | [
"3beta-hydroxy-Delta(5)-C27-steroid oxidoreductase"
] | {"catalytic_activity": ["7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one +", "NADH + H(+)."], "comments": ["-!- Highly specific for 3beta-hydroxy-C27-steroids with Delta(5)-double", "bond."], "uniprot_count": 4} |
bio/ec | 1.1.1.182 | Transferred entry: 1.1.1.198, 1.1.1.227 and 1.1.1.228 | null | 1.1.1.- | deprecated | [] | {"uniprot_count": 0} |
bio/ec | 1.1.1.183 | geraniol dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(2E)-geraniol + NADP(+) = (2E)-geranial + NADPH + H(+)."], "comments": ["-!- Also acts, more slowly on farnesol but not on nerol.", "-!- The enzyme produces a mixture known as citral, which includes", "geranial and neral.", "-!- It is still not known whether neral is produced directly by the", ... |
bio/ec | 1.1.1.184 | carbonyl reductase (NADPH) | null | 1.1.1.- | null | [
"aldehyde reductase I",
"NADPH-dependent carbonyl reductase",
"prostaglandin 9-ketoreductase",
"xenobiotic ketone reductase"
] | {"catalytic_activity": ["a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)."], "comments": ["-!- Acts on a wide range of carbonyl compounds, including quinones,", "aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins", "E and F, reducing them to the corresponding alcohol.", "-!- Si-specific with re... |
bio/ec | 1.1.1.185 | L-glycol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(1) an L-glycol + NADP(+) = a 2-hydroxycarbonyl + NADPH + H(+).", "(2) an L-glycol + NAD(+) = a 2-hydroxycarbonyl + NADH + H(+)."], "comments": ["-!- The 2-hydroxycarbonyl compound formed can be further oxidized to a", "vicinal dicarbonyl compound.", "-!- In the reverse direction, vicinal diket... |
bio/ec | 1.1.1.186 | dTDP-galactose 6-dehydrogenase | null | 1.1.1.- | null | [
"thymidine-diphosphate-galactose dehydrogenase"
] | {"catalytic_activity": ["dTDP-D-galactose + 2 NADP(+) + H2O = dTDP-D-galacturonate + 2 NADPH +", "3 H(+)."], "uniprot_count": 0} |
bio/ec | 1.1.1.187 | GDP-4-dehydro-D-rhamnose reductase | null | 1.1.1.- | null | [
"GDP-4-keto-6-deoxy-D-mannose reductase",
"GDP-4-keto-D-rhamnose reductase",
"guanosine diphosphate-4-keto-D-rhamnose reductase"
] | {"catalytic_activity": ["(1) GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + NADH", "+ H(+).", "(2) GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose +", "NADPH + H(+).", "(3) GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose", "+ NADPH + H(+).", "(4) GDP-6-deoxy-alpha... |
bio/ec | 1.1.1.188 | prostaglandin-F synthase | null | 1.1.1.- | null | [
"PGD2 11-ketoreductase",
"PGF synthetase",
"prostaglandin 11-ketoreductase",
"prostaglandin-D2 11-ketoreductase",
"prostaglandin-D2 11-reductase",
"prostaglandin-D2 ketoreductase",
"prostaglandin-F synthetase"
] | {"catalytic_activity": ["prostaglandin F2alpha + NADP(+) = prostaglandin D2 + NADPH + H(+)."], "comments": ["-!- Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2;", "prostaglandin D2 is not an intermediate in the reduction of", "prostaglandin H2.", "-!- Also catalyzes the reduction of a number of carbo... |
bio/ec | 1.1.1.189 | prostaglandin-E2 9-reductase | null | 1.1.1.- | null | [
"9-keto-prostaglandin E2 reductase",
"9-ketoprostaglandin reductase",
"PGE2 9-ketoreductase",
"PGE2 9-oxoreductase",
"prostaglandin-E2 9-oxoreductase"
] | {"catalytic_activity": ["prostaglandin F2alpha + NADP(+) = prostaglandin E2 + NADPH + H(+)."], "comments": ["-!- Reduces prostaglandin E2 to prostaglandin F2alpha.", "-!- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can", "also be reduced to the corresponding hydroxy compounds.", "-!- May be identical ... |
bio/ec | 1.1.1.190 | indole-3-acetaldehyde reductase (NADH) | null | 1.1.1.- | null | [
"indoleacetaldehyde reductase"
] | {"catalytic_activity": ["indole-3-ethanol + NAD(+) = indole-3-acetaldehyde + NADH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.191 | indole-3-acetaldehyde reductase (NADPH) | null | 1.1.1.- | null | [] | {"catalytic_activity": ["indole-3-ethanol + NADP(+) = indole-3-acetaldehyde + NADPH + H(+)."], "uniprot_count": 2} |
bio/ec | 1.1.1.192 | long-chain-alcohol dehydrogenase | null | 1.1.1.- | null | [
"fatty alcohol oxidoreductase"
] | {"catalytic_activity": ["a long-chain primary fatty alcohol + 2 NAD(+) + H2O = a long-chain fatty", "acid + 2 NADH + 3 H(+)."], "comments": ["-!- Hexadecanol is a good substrate."], "uniprot_count": 3} |
bio/ec | 1.1.1.193 | 5-amino-6-(5-phosphoribosylamino)uracil reductase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-", "(5-phospho-D-ribosylamino)uracil + NADPH + H(+)."], "uniprot_count": 24} |
bio/ec | 1.1.1.194 | coniferyl-alcohol dehydrogenase | null | 1.1.1.- | null | [] | {"catalytic_activity": ["(E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+)."], "comments": ["-!- Specific for coniferyl alcohol; does not act on cinnamyl alcohol,", "4-coumaryl alcohol or sinapyl alcohol."], "uniprot_count": 2} |
bio/ec | 1.1.1.195 | cinnamyl-alcohol dehydrogenase | null | 1.1.1.- | null | [
"CAD"
] | {"catalytic_activity": ["(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)."], "comments": ["-!- Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol and", "cinnamyl alcohol (cf. EC 1.1.1.194)."], "uniprot_count": 58} |
bio/ec | 1.1.1.196 | 15-hydroxyprostaglandin-D dehydrogenase (NADP(+)) | null | 1.1.1.- | null | [
"prostaglandin-D 15-dehydrogenase (NADP(+))",
"prostaglandin-D 15-dehydrogenase (NADP+)"
] | {"catalytic_activity": ["prostaglandin D2 + NADP(+) = 15-oxoprostaglandin D2 + NADPH + H(+)."], "comments": ["-!- Specific for prostaglandins D (cf. EC 1.1.1.141 and EC 1.1.1.197)."], "uniprot_count": 11} |
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